For one-semester or two-semester introductory courses in Biochemistry. May be taught out of departments of chemistry, biology, or biochemistry. Biochemistry departments may be in faculties of science or in medicine.This concise, introductory text focuses on the basic principles of biochemistry, filling the gap between the encyclopedic volumes and the cursory overview texts. The book has a well-deserved reputation for being the most accurate biochemistry textbook in the market. Widely praised in its previous edition for currency, and clarity of exposition, the new edition has been thoroughly revised and updated to reflect recent changes in this dynamic discipline. Unique focus on principles and underlying themes of biochemistry. Fosters understanding rather than simply relating facts, establishing a framework of key principles which are then reinforced with the careful use of illustrative examples. Also, encourages understanding over memorization. (Ex. Chapter 6: Mechanisms of Enzymes.)Balanced coverage of biomolecular structure/function, metabolism, and molecular biology. Includes a chapter on photosynthesis. Provides instructors with thorough, consistent coverage of all the topics they cover in class. Emphasis on the relationship between structure and function. Material in the later chapters builds on principles in the first part of the book. (Ex. Chapter 20: Transcription and RNA Processing.)Strong chemical focus-Including mechanisms of reactions and attention to the physical chemistry of biomolecules. Explains how and why reactions happen so students can understand more and memorize less. (Ex. Chapter 7: Coenzymes.) New emphasis on oxidation-reduction reactions.Expands coverage of these important reactions and explains electron gain and loss in a simple and straightforward manner. Principles and concepts are covered in a revised chapter on metabolic strategies. Electron transport and photosynthesis chapters have been extensively revised. Evolutionary Approach to biochemistry. The fundamental strategies of metabolic pathways are explained from the perspective of how they evolved. The fourth edition places more emphasis on biosynthesis pathways since they are of fundamental importance for most species. Catabolic pathways are usually described after the synthesis of particular biomolecules has been explained. (Exception: glycolysis.) This extends a trend that has been developing in all biochemistry textbooks over the past decade. Authoritatively written by a collaborative team of experts. Provides students with clear, lucid explanations and accurate science for all areas of biochemistry. (Ex. DNA replication.)Chapters on amino acid, lipid, and nucleotide metabolism stress core concepts. Students leaves this short course with a good understanding of the key issues of metabolism and don't lose sight of the forest for the trees. NEW - Completely updated to reflect the latest understanding and discoveries in biochemistry-Maintains the standard of currency and accuracy set by the previous edition. Provides the most up-to-date coverage of the material. Ex. Electron transport. Incorporates information from genome sequencing projects in order to understand which metabolic pathways are present in an organism and which enzymes are used. (Ex. Citric acid cycle, Lipid metabolism.) Excellent coverage of gene expression-Including the structure of RNA polymerase, the structure of the ribosome, genome organization, repair mechanisms, regulation of transcription and translation, and the structure and evolution of aminoacyl tRNA synthetases. Offers the most up-to-date treatment of molecular biology available in this rapidly changing area. (Ex. Ribosome structure.)NEW - Many new protein structures. Reflecting recent developments in technology and understanding, the book helps students appreciate the intricacies and dynamics of macromolecular structure. NEW - Boxes focus on interesting science, commercial applications of biochemistry, and medical relevance. New boxes on enzyme evolution, enzyme microheterogeneity, sources of electrons in redox reactions, and the origins of common names help stimulate student's interest in the science of biochemistry. New boxes on genetically modified foods and improving crop production illustrate some of the commercial applications of biochemistry. New boxes on ABO blood groups, statins, and common painkillers illustrate principles described in the text using clinical examples.