Protein Degradation v 1

The first volume in a new series dedicated to protein degradation, this book explains the fundamentals of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad overview of protein degradation and its functions in cellular regulation, it then goes on to discuss the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated; this includes latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, the roles of the ubiquitin pathway in regulating key cellular processes, and its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.