The Yearbook of Medical Informatics gives an overview of the latest significant research activities in the field of Health and Medical Informatics. It contains original papers from the categories Health and Clinical Management, Patient Records, Health InformationSystems, Signal Processing, Knowledge Processing and Decision Support, Computer SuppOrted Education, Bioinformatics. This year's special research section highlights: Medical Imaging Informatics. Images of vorious modalities and dimensions play an important role in diagnosis, therapy and treatment. Several computer science disciplines, ranging from IMAGE Processing, Virtual Reality, Computer Graphics and Visionto Robotics, work hand in hand to handle the huge amount of data, and to reap as many benefits from them as possible. The special section presents some of the most impressive research papers in this challenging field.