This is a general introduction for postgraduate trainees in pathology, neuropathology and other branches of the neurosciences, covering all aspects of the pathology of the central nervous system, the peripheral nervous system, muscle and the orbit. Emphasis is also placed on the pathogenesis and clinical implications of structural changes.All chapters have been updated to take account of developments in the various aspects of diseases of the nervous system, particularly in the fields of head injury, demyelinating diseases, deficiency disorders, developmental and perinatal disorders, ageing and the dementias, and AIDS. The chapter on tumours has been recast to conform to new WHO recommendations. The chapters on diseases of muscle and of peripheral nerves have been completely rewritten by internationally recognised authorities in their fields - Dr. Janice R. Anderson of Addenbrooke's Hospital, Cambridge and Dr. Rosalind H. M. King of the Royal Free Hospital, London respectively. Two entirely new chapters cover clinical neuropathology and the diseases of the orbit. Throughout there is greater emphasis on immunohistochemistry, which has become an increasingly essential adjunct to clinical practice. All users of this book will find that it provides a much-needed general review, giving them a fuller understanding of the subject and helping them to examine autopsy and biopsy material confidently, intelligently and methodically.