The leading reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients, this all-inclusive, multidisciplinary text covers the ever-widening sphere of current cancer knowledge and clinical practice. In this new sixth edition, an outstanding editorial team from world-renowned medical centers presents a comprehensive yet manageable resource for all aspects of oncology. This text continues its leading pace with new and updated information on biology, immunology, etiology, epidemiology, clinical trials, prevention, screening and early detection, pathology, imaging, and therapies. The 162 comprehensive chapters are organized into six parts: Cardinal Manifestations of Cancer, Scientific Foundations of Cancer, Principles of Cancer Diagnosis, Principles of Therapeutic Modalities, Principles of Multidisciplinary Management, and Cancer Management. This edition sees expanded chapters on tumor immunology, and on the theory and practice of clinical trials. Completely new chapters focus on the cardinal manifestations of cancer, targeted therapy, pregnancy and cancer, cancer and aging, central nervous system metastases, primary central nervous system tumors, bone tumors, unique pathological features of childhood cancer and special considerations for adolescents and young adults. Cancer Medicine, Sixth Edition, features hundreds of color and black-and-white illustrations and photographs, tables, graphs and algorithms that make this text a valuable clinical tool in recognizing characteristic appearances of both patient and tissue.