The contributors of this edition focus on the expanded role of breast cytopathology. Breast fine needle aspiration biopsy is thoroughly examined, including articles on proposed practice guidelines, image-directed in nonpalpable breast lesions, integration, comparison to core needle biopsy and medicolegal issues. Further articles discuss intraoperative imprint cytology, cytomorphology as a risk predictor, molecular targeted therapy, and assessment of prognosic factors in cytologic preparation. Reviews on the cytomorphology of benign breast disease, fibrocystic change, malignant breast lesions, and uncommon breast lesions are also included.