Genomics in Drug Discovery and Development

This book addresses the needs of drug discovery scientists and managers planning to initiate their own toxicogenomics programs or acquire access to an existing database. The book introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox by discussing all aspects of microarray technology, describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis. The authors provide a comprehensive resource for pharmaceutical discovery scientists who involved in laboratory or modeling studies aimed at early assessment of the toxicity and efficacy of drug candidates. In addition, the books inclusion of pharmacogenomics and pharmacogenetics enables discovery scientists to position their studies in the context of clinical trials.