Pharmacokinetic and Pharmacodynamic Data Analysis

Pharmacokinetic and Pharmacodynamic Data Analysis provides an introduction into pharmacokinetic (PK) and pharmacodynamic (PD) concepts using simple illustrations and reasoning. It describes ways in which pharmacokinetic and pharmacodynamic theory may be used to give insight into modelling questions and how these questions can in lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts and principles of mathematical modelling, while the second provides case studies obtained from the drug industry and academia. This book will be of interest to researchers, graduate students and advanced undergraduates in the PK/PD area who wish to learn how to analyse biological data and build models, and to become familiar with new areas of application. It will also be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modelling.