Berrilyn J Ferguson and Allen Seiden are considered the to physicians in the field of chronic rhinosinusitis. They have joined forces on this issue and have gathered the biggest and most well-known visionaries in the field, most of whom have authored books on the topic. This issue focuses on the recently-discovered pathologies of chronic rhinosinusitis moreso than surgical techniques. Bacterias, airborne pathogens, mucositis, autonomic functions, biofilms, and antigens will be covered.