A multi-author work with contributions from key investigators in the septin field. Coverage includes: Septins in different model organisms (yeast, worm, fly, mammals) Septin evolution Septin genomics Septin gene regulation Septin biochemistry Septins and other filament systems Septins and membranes Septins and cytokinesis Septin-interacting proteins Septins and signaling pathways Septins and human disease Including septins and neoplasia, neuro-degenerations, infectious disease, hemostasis, infertility Septins and stress responses including hypoxia An appendix is included with details of the septin genes in various systems, including the complex splicing patterns in mammals. Â